Oral Insulin Delivery Cover Image (And Associated Syracuse Research Article) in ChemMedChem

You've heard about it, you've read about it, you've seen it on color TV, you've even seen it streamed. The cover story in this month's issue of ChemMedChem is a communication by members and collaborators of the Robert Doyle Group here at Syracuse University. The report describes the B12/TCII-based uptake of insulin, a process that occurs via the ingestion of a B12-insulin conjugate. In case you missed that, the delivery is oral, not by needle. For those of us that pass out at anything needle-related at about the time that the alcohol wipe is opened, that's a positive step forward for getting rid of any syringe-related medicine altogether.

full image

With the cover story comes the cover image shown above, a structure calculation on the insulin-B12/TCII complex. The bases for this structure can be found in the Protein Data Bank, including the TCII-B12 complex reported in PDB entry 2BB5 (the only hack in the structure calculation involved the replacement of the cobalt for iron to use already available bond parameters) and the insulin structure reported in PDB entry 1ZNI. The covalent attachment of the insulin to B12 can be found in the article. Structure manipulation was performed with a combination of NanoEngineer-1 and VMD, VMD being included in the mix in order to generate the ribbon renderings of the insulin and TCII protein backbones. As for the accuracy of the calculation, time and a synchrotron X-ray source will tell.

For much more information and numerous links to new stories related to the research in the article, I direct you to the group website of Robert Doyle and the various links to news stories available in his departmental publication list.

chemmedchem cover
From ChemMedChem. Click HERE to go to the article.

From the website:

Cover Picture: Vitamin B12 as a Carrier for the Oral Delivery of Insulin (ChemMedChem 12/2007). The cover picture shows an orally active, glucose-lowering vitamin B12-insulin conjugate bound to the B12 uptake protein transcobalamin II (TCII). The inset shows a close-up view of the TCII binding pocket. (Insulin is in red; vitamin B12 is in bright yellow.) For details, see the Communication by T. J. Fairchild, R. P. Doyle, et al. on p. 1717 ff.

www3.interscience.wiley.com/journal/110485305/home
chemistry.syr.edu/faculty/doyle.html
www.syr.edu
www3.interscience.wiley.com/cgi-bin/abstract/117354616/ABSTRACT?CRETRY=1&SRETRY=0
en.wikipedia.org/wiki/B12
en.wikipedia.org/wiki/Insulin
en.wikipedia.org/wiki/Transcobalamin
www3.interscience.wiley.com/journal/117354609/graphissue
www.rcsb.org/pdb
www.rcsb.org/pdb/explore.do?structureId=2BB5
www.rcsb.org/pdb/explore.do?structureId=1ZNI
www.nanorex.com
www.ks.uiuc.edu/Research/vmd
en.wikipedia.org/wiki/Synchrotron
chemistry.syr.edu/faculty/doyle_group/index.html
chemistry.syr.edu/faculty/doyle.html#pubs

"In the future, it will be the little things that really matter."

The latest publication (Vol. 15 No.3 2006) from the Business and Economic Research Center (BERC) at the Middle Tennessee State University features an excellent article by Dr. Richard W. Oliver and Ed Sperling on the growing influence of nanotechnology and some updated graphics that wouldn't have come out as well as they did without NanoEngineer-1. Click on the pdf, which'll open a linked Table of Contents to the whole article.

I'm not much for presenting critical discussions of content (that whole "spare time" thing), so will keep it brief. It is a very good, non-technical (well, non-technical to ME anyway) discussion of how our continued understanding of the nanoscale is shaping developments in all industries. While some general science is intermixed throughout, the focus of the article is on the shaping of economies, or how the current nanotech weather will eventually become the eye of the storm of the global manufacturing climate. I tend to not look far beyond my own computer screen as I push ahead in the field, so I very much enjoy reading coherent presentations of nanotech aspects I wouldn't otherwise spend much time thinking about (yes, there are many in nanotechnology wondering IF we should, HOW we should, WHEN we should, WHAT we should and WHY we should, and many of those in the field have orthogonal interests that could all benefit from larger coefficients in their off-diagonal elements). That's what makes David Berube's Nano-Hype so interesting to read and Rob Tow so interesting to listen to.

And it wouldn't be a Tennessee nanotechnology article without some mention of Battelle, the current managing organization for Oak Ridge National Lab and other driving force, along with Foresight Nanotech Institute, of the Technology Roadmap for Productive Nanosystems.

www.ornl.gov
www.mtsu.edu
www.battelle.org
www.tauzero.com
www.nanorex.com
www.richardwoliver.com
www.foresight.org/roadmaps
www.mtsu.edu/~berc/home.html

www.cas.sc.edu/ENGL/faculty/berube
www.amazon.com/gp/product/1591023513/sr=1-1/…
www.findarticles.com/p/search?tb=art&qt=%22Ed+Sperling%22"